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In turn, this may promote symptom relief and disease prevention

Declarations Competing Interests The authors declare no competing interests

These effects accumulate in brain tissue and persist longer than the compound remains in the bloodstream: A single dose's effects on synaptic density, VEGF signalling, and neuroprotective cascades may last for hours or days after blood levels have dropped to zero Repeated dosing likely leads to cumulative effectseach dose "adds to" the previous dose's neurobiological changes Anecdotal reports of sustained effects after discontinuation (weeks to months in some cases) are consistent with persistent brain changes rather than active drug presence Implications for Dosing This is a crucial point: the observation that effects outlast blood concentrations explains why some community members report benefits from periodic (not daily) dosing and why cycling protocols exist

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The three compounds, in a rigorous research approach, require: strict analytical control (MS + HPLC 98%), adapted administration route (intranasal for BBB crossing), standardised behavioural model with positive control, and exhaustive documentation for publication